Table of Contents

HK J Paediatr (New Series)
Vol 19. No. 2, 2014

HK J Paediatr (New Series) 2014;19:71-74

Original Article

An Examination of the Effects of Phenobarbital on Thyroid Function Tests in Childhood Epilepsy

A Cayir, MI Turan, IS Esin


Aim: The aim of this study was to evaluate changes in thyroid function tests in a group of epileptic children taking phenobarbital. Materials and Methods: Patients' demographic data and free thyroxine (FT4), free triiodothyronine (FT3) and thyroid-stimulating hormone (TSH) levels during at least 12 months of treatment were recorded. Forty-eight children using phenobarbital and 45 healthy children were enrolled. Results: In the phenobarbital group, FT3 level was 4.14±0.1 pg/mL, FT4 1.22±0.01 ng/dL and TSH 2.88±0.21 mIU/L. In the control group, FT3 level was 4.28±0.08 pg/mL, FT4 1.34±0.02 ng/dL and TSH 2.28±0.19 mIU/L. The rates of subclinical hypothyroidism between the two groups were not show statistically significant difference (p=0.16). Conclusion: The use of phenobarbital in the treatment of childhood epilepsy does not appear to increase the risk of thyroid dysfunction.

目的:本研究旨在評估在一組癲癇患兒服用苯巴比妥後,其甲狀腺功能的變化。資料與方法:參照和對比病人的基本資料和在至少12個月的治療過程中游離甲狀腺素(FT4)、游離三碘甲腺原氨酸(FT3)和促甲狀腺激素(TSH)水平。由45名使用苯巴比妥患兒和48名健康兒童參加。結果:苯巴比妥組,FT3水平為4.14±0.1 pg/mL,FT4 1.22±0.01 mg/dL和TSH 2.88±0.21 ml U/L。在對照組中,FT3水平為4.28±0.08 pg/mL,FT4 1.34±0.02 mg/dL和TSH 2.28±0.19 ml U/L。兩組亞臨床狀腺功能不足的發生率無統計學上顯著差異(p=0.16)。結論:在兒童腦癇的治療中使用苯巴比妥不會增加甲狀腺功能不全的風險。

Keyword : Child; Epilepsy; Phenobarbital; Thyroid function test



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