Table of Contents

HK J Paediatr (New Series)
Vol 16. No. 2, 2011

HK J Paediatr (New Series) 2011;16:77-84

Original Article

Frequency of Low Bone Mineral Density and Its Associated Factors in Patients with Juvenile Systemic Lupus Erythematosus

MY So, CC Mok, KM Ma, AWL Kwok, PC Leung, SN Won


Objective: To evaluate the frequency of low bone mineral density (BMD) in Chinese patients with juvenile systemic lupus erythematosus (JSLE) and the associated protective and risk factors. Methods: We evaluated the BMD in 21 patients with JSLE with a mean age at diagnosis of 13.6±2.1 years. All patients had at least one BMD measurement by dual-energy X-ray absorptiometry at lumbar spine (L2-4) and femoral area at or beyond the age of 18. The correlations between BMD and cumulative dose of steroids, disease duration, disease activity, disease-related damage, clinical features, body mass index and age were investigated. Results: 'Low BMD for chronological age' (Z-score ≤-2.0) at one or more sites was seen in three patients (14.3%) and 'osteopenia' (Z-score <-1.0 and >-2.0) at any site was present in 12 patients (57.1%). Multiple linear regression analyses showed that body mass index was a positive predictor for BMD at all sites. Cumulative steroid dose, disease activity or lupus nephritis were not related to low BMD. Conclusions: Low bone mineral density is a common problem among Chinese patients with JSLE. Lower body mass index was shown to be a possible risk factor for low BMD.

Keyword : Bone mineral density; Children; Chinese; Juvenile; Systemic lupus erythematosus

Abstract in Chinese


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