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HK J Paediatr (New Series)
Vol 3. No. 1,
1998
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HK J Paediatr (New Series) 1998;3:68-70
Case Report
Treating Factor VII Deficiency: Fresh Frozen Plasma or Factor VII Concentrate?
ACW Lee, KW Wong, SC Szeto, KS Tong, KT So Department of Paediatrics, Tuen Mun Hospital, Tuen Mun, New Territories, Hong Kong, China ACW Lee ( 李志偉 ) MRCP KW Wong ( 黃國榮 ) MRCP KS Tong ( 唐繼昇 ) LMCHK KT So ( 蘇均堂 ) FRCP Department of Clinical Pathology, Tuen Mun Hospital, Tuen Mun, New Territories, Hong Kong, China SC Szeto ( 司徒紹昌 ) FRCPath Correspondence to: Dr ACW Lee Received March 7, 1998
Abstract A 3-year-old Chinese boy with congenital factor VII deficiency presented with recurrent gastrointestinal bleeding, epistaxis, hemarthrosis and soft tissue bleeding. The hemorrhagic symptoms were ameliorated with infusions of fresh frozen plasma, but it was complicated by hyperalbuminemia, hypergammaglobulinemia and hypertension. When the treatment was switched to plasma-derived factor VII concentrate, hemostatic control improved with resolution of the complications, Although factor VII concentrate is expensive, it may be the preferred treatment in the patient with severe factor VII deficiency in terms of clinical efficacy and cost effectiveness. Keyword : Child; Factor VII concentrate; Factor VII deficiency; Treatment Abstract in Chinese
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