SWY Lau, LLY Tsung

Abstract

Cytotoxic lesion of the corpus callosum (CLOCC), in the past is known as mild encephalitis/encephalopathy with reversible splenial lesion (MERS), reversible splenial lesion syndrome, or transient splenial lesions. CLOCC is a new normenclature which describes cytotoxic injury on the corpus callosum secondary to various aetiologies. Magnetic resonance imaging of brain demonstrates lesions with characteristic high-signal intensity on T2-weighted images with restricted diffusion in diffusion-weighted images over corpus callosum which are often reversible. Early recognition of CLOCC and treatment of the underlying aetiology leading to good neurological recovery in most cases. Proper counselling of CLOCC with good prognosis may lessen parental anxiety.