Hong Kong Journal of Paediatrics [HK J Paediatr (New Series) 2022;27:126-131]

Department of Pediatrics, Bezmialem Vakif University Medical Faculty, Istanbul, Turkey
MC Kiyak MD

Department of Pediatrics, Bezmialem Vakif University, Istanbul , Turkey
FU Kahraman MD
AH Gedik MD
E Çakir MD

Department of Biochemistry, Bezmialem University Hospital, Istanbul, Turkey
A Kocyigit MD

Division of Pediatric Hematology-Oncology, Bezmialem Vakif University, Istanbul, Turkey
FB Çakir MD

Department of Pediatrics, Division of Pediatric Allergy and Immunology, Bezmialem Vakif University School of Medicine, Istanbul, Turkey
M Nursoy MD

Correspondence to: Dr FU Kahraman

Email: feyza.kahraman1980@gmail.com

Received November 26, 2020

Background: The aim of this study was to measure the serum levels of myeloperoxidase (MPO), paraoxonase (PON1) and arylesterase (ARE) in paediatric patients with non-cystic fibrosis bronchiectasis (non-CF BE), and to compare these results with healthy controls. Methods: A total of 101 paediatric patients with non-CF BE and 70 age- and sex-matched healthy controls were enrolled into the study between November 2010 and November 2015. The levels of MPO, PON1 and ARE were measured in all participants. Findings: Compared to controls, MPO levels were significantly lower (p=0.001), while PON1 and ARE levels were significantly higher in the patient group (p=0.001). Conclusion: Our study reports that the oxidant and anti-oxidant enzyme levels in non-CF BE differ from healthy controls; thus, suggesting a role in non-CF BE pathophysiology.