Table of Contents

HK J Paediatr (New Series)
Vol 27. No. 2, 2022

HK J Paediatr (New Series) 2022;27:107-112

Original Article

Are the Neutrophil-to-lymphocyte, Platelet-to-lymphocyte and Monocyte-to-lymphocyte Ratios Predictive Factors for the Retinopathy of Prematurity?

A Ugurlu, E Icel


Introduction: In this study, we aimed to evaluate the possible relationship between the neutrophil-to-lymphocyte, monocyte-to-lymphocyte and platelet-to-lymphocyte ratio and retinopathy of prematurity (ROP). Material and Method: The data of 348 patients who applied to Erzincan University Ophthalmology Unit for screening the retinopathy of prematurity were analysed retrospectively. One hundred sixty seven patients who were collected CBC samples within the first 72 hours after delivery and who met the inclusion criteria were included in the study. Infants with a gestational age of ≤35 week were screened for ROP. Pateints were divided into two groups. Group 1 was involved the patients with the diagnosis of ROP and group 2 was involved the normal patients (no ROP). The levels of NLR, PLR and MLR were determined in two groups. Results: Fifty-nine patients who were detected ROP are in group 1 and 108 patients who were not seen ROP are in group 2 in the study. The mean gestational age at birth of the patients was 30.4±2.1 [26-34] weeks in group 1 and 33.7±1.7 [27-35] weeks in group 2 (P=0.004). The mean gestational weigth at birth was 1927.2±158.4 [1690-2300] gram in group 1 and 2169.1±283.1 [1750-3100] gram in group 2. (P<0.001) With the result of logistic regression analysis, gestational age [Odds Ratio(OR): 0.531, 95%CI: 0.388-0.726, P<0.001], NLR [OR:34.849, 95%CI: 2.091-580.779, P=0.013] and PLR [OR: 1.067, 95%CI: 1.034-1.110, P<0.001] were detected the independent risk factors for ROP. Conclusion: Our study revealed that higher NLR and PLR which are evaluated with in first 72h after birth is an independent predictor of ROP.

Keyword : Lymphocyte; Monocyte; Neutrophil; Platelet; Retinopathy of prematurity


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