XF Yang, B Ze, Y Dai, L Zhu, C Chen

Abstract

Objective: To investigate the relationship between cytokines serum levels at postnatal 4-6 weeks and retinopathy of prematurity (ROP). Method: Six premature infants having stage 2 or more ROP were enrolled as ROP group and four premature infants without ROP as the control group. The factors including gestational age, birth weight and gender were not significantly different in the two groups. Human antibody arrays were used, including 507 cytokines, to identify which cytokine serum levels were different in ROP group and control group at 4-6 weeks postnatal age. SPSS 16.0 was carried out to analyse the data. Result: The serum levels of 26 cytokines in ROP group are significantly different from those in the control group at 4-6 weeks postnatal age by AAH-BLG-1, including chemotacic factors, inflammatory factors etc. Eighteen cytokines serum levels were higher and 8 were lower in ROP group. Conclusion: The serum levels of cytokines at 4-6 weeks postnatal age are related to ROP, including chemotacic factors, inflammatory factors etc.

目的：研究血清細胞因數水平（4-6週齡）和早產兒視網膜病（ROP）的關係。方法：ROP組6例，為早產兒ROP 2期或以上；對照組4例，未合併ROP的早產兒。胎齡、出生體重和性別等因素，兩組間無顯著性差異。使用人抗體陣列（包括507細胞因數）來鑒定哪些細胞因數血清水平生後4-6週時在兩組間有差異。資料分析採用SPSS 16.0。結果：26種細胞因數血清水平（通過AAH-BLG-1測定）在生後4-6週時，ROP與對照組相比有顯著性差異，包括趨化因數，炎症因數等。其中18種細胞因數血清水準在ROP組升高，8種細胞因數水平在ROP組降低。結論：在生後4-6週時，細胞因數血清水平與ROP相關，包括趨化因數、炎症因數等。