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HK J Paediatr (New Series)
Vol 19. No. 3,
2014
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HK J Paediatr (New Series) 2014;19:188-191
Case Report
Acute Post-streptococcal Glomerulonephritis with Normal Range Complement C3 Level: Three Case Reports
GL Qian, L Huang, JH Mao, AM Liu Nephrology Ward, Children's Hospital, Zhejiang University School of Medicine, 57 ZhuganXiang, Hangzhou, 310003, China L Huang (黃雷) MD HJ Mao (毛建華) PhD AM Liu (劉愛民) PhD Department of Genetics and Metabolism, Children's Hospital, Zhejiang University School of Medicine, 57 ZhuganXiang, Hangzhou, 310003, China GL Qian (錢古柃) MD Correspondence to: Dr L Huang Received June 12, 2013
Abstract Introduction: Acute post-streptococcal glomerulonephritis (APSGN) is a common disease that primarily affects children. At the acute phase of post-streptococcal glomerulonephritis, the level of haemolytic complement plasma C3 always decreases. The hypocomplementaemia is one of the important criteria for diagnosis of APSGN. We identified 3 children with acute post-streptococcal glomerulonephritis diagnosed clinically and pathologically whose plasma C3 levels remained normal range in the acute phase. Case presentation: All of the three patients are Chinese (a 5.8-year-old boy, a 8.8-year-old girl, and a 6.9-year-old girl). Their plasma C3 levels were 0.99 g/L, 0.64 g/L, and 0.66 g/L (normal range: 0.5-1.5 g/L) in the acute phase. Pathological findings showed that subepithelial hump-like dense deposits were present.Conclusion: It is possible for patients with APSGN that serum complement C3 level remains normal range during acute phage. Even if plasma C3 levels are still normal, the possibility of acute post-streptococcal glomerulonephritis cannot be ignored. Renal biopsy and follow-up of C3 level variation will be necessary for definite diagnosis of these patients. Keyword : Acute post-streptococcal glomerulonephritis; Haemolytic complement plasma C3; Kidney biopsy Abstract in Chinese
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