Table of Contents

HK J Paediatr (New Series)
Vol 18. No. 4, 2013

HK J Paediatr (New Series) 2013;18:204-209

Original Article

Predictors of Intravenous Immunoglobulin Resistance in Chinese Children with Kawasaki Disease

JHM Young, KF Huen, LTW Chan


Abstract

Objectives: To investigate predictors of intravenous immunoglobulin (IVIG) resistance in children with Kawasaki Disease (KD). Methods: A retrospective cohort study of children, divided into IVIG-responsive and IVIG-resistant groups, diagnosed with KD and treated with IVIG at Tseung Kwan O Hospital. Demographic, clinical and laboratory data before IVIG treatment and coronary abnormalities were analysed. Results: 82 children, all were Chinese, with KD were studied. IVIG-resistant rate was 19.5%. Univariate analysis revealed that the IVIG-resistant group had higher neutrophil percentage (p=0.015) and serum total bilirubin level (p=0.033) but lower serum albumin level (p=0.026) and lymphocyte percentage (p=0.024). Multivariable logistic regression analysis revealed that the IVIG-resistant group had lower serum albumin level (odds ratio (OR) 0.776, 95% confidence interval (CI) 0.618-0.975, p=0.03) and higher neutrophil percentage (OR 1.169, 95% CI 1.017-1.344, p=0.029). Conclusions: Low serum albumin level and high neutrophil percentage were independent predictors of IVIG resistance in Chinese children with KD.

Keyword : Immunoglobulin, intravenous; Mucocutaneous lymph node syndrome


Abstract in Chinese

 
 

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