Table of Contents

HK J Paediatr (New Series)
Vol 17. No. 2, 2012

HK J Paediatr (New Series) 2012;17:97-102

Original Article

Permissive Approach and Relationship to Outcomes of Infants <27 Weeks Gestation
寬鬆處理方法與少於孕27週嬰幼兒的預後關係

A Lee, XY Ye, PS Shah


Abstract

Purpose: To determine profiles of carbon dioxide (PaCO2), pH and blood pressure (BP) in preterm infants (<27 weeks gestational age) in relation to mortality or any of three severe morbidities: (a) severe neurological injury, (b) severe retinopathy or (c) chronic lung disease. Methods: Profiles of pH, PaCO2 and BP in the first week and outcomes were analysed by dividing infants in three groups: (1) no morbidities (n=73); (2) with one/two morbidities (n=125), and (3) death or all three morbidities (n=56). Results: Mean pH were higher for Groups 1 and 2 compared to Group 3. Mean PaCO2 values were normal and lower for Group 1 compared to Groups 2 and 3. Mean BP was not different between three groups. Conclusion: Preterm infants with no morbidities had pH and PaCO2 values near normal range whereas infants with significant morbidities or mortality had values in the so-called "permissive" range.

目的:探討早產兒(<27週)的二氧化碳分壓(PaCO 2)、pH值和血壓(BP)與死亡率或三個嚴重併發症:(a)嚴重的神經損傷,(b)嚴重的視網膜病變或(c)慢性肺部疾病,是否存在任何關係。方法:嬰兒分為三組:(1)無併發症組(n=73);(2)一種/兩種併發病(n=125),(3)死亡或所有三種併發病(n=56)於出生後第一週分析pH值,PaCO2和BP之間的關係。結果:第1和第2組的平均pH值分別高於第3組,第1組的平均二氧化碳分壓值正常及低於第2組和第3組。三組之間的平均血壓沒有差異。結論:早產兒的pH值和PaCO 2值接近正常範圍時並無出現併發症,而在所謂的「寬鬆」範圍值,嬰兒普遍有較高的發病率或死亡率。

Keyword : Acidosis; Hypotension; Infant-premature; Outcome; Permissive hypercapnia

關鍵詞:酸中毒、低血壓、早產兒、預後、允許性高碳酸血症

 
 

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