Table of Contents

HK J Paediatr (New Series)
Vol 17. No. 2, 2012

HK J Paediatr (New Series) 2012;17:97-102

Original Article

Permissive Approach and Relationship to Outcomes of Infants <27 Weeks Gestation

A Lee, XY Ye, PS Shah


Purpose: To determine profiles of carbon dioxide (PaCO2), pH and blood pressure (BP) in preterm infants (<27 weeks gestational age) in relation to mortality or any of three severe morbidities: (a) severe neurological injury, (b) severe retinopathy or (c) chronic lung disease. Methods: Profiles of pH, PaCO2 and BP in the first week and outcomes were analysed by dividing infants in three groups: (1) no morbidities (n=73); (2) with one/two morbidities (n=125), and (3) death or all three morbidities (n=56). Results: Mean pH were higher for Groups 1 and 2 compared to Group 3. Mean PaCO2 values were normal and lower for Group 1 compared to Groups 2 and 3. Mean BP was not different between three groups. Conclusion: Preterm infants with no morbidities had pH and PaCO2 values near normal range whereas infants with significant morbidities or mortality had values in the so-called "permissive" range.

Keyword : Acidosis; Hypotension; Infant-premature; Outcome; Permissive hypercapnia

Abstract in Chinese


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