Table of Contents

HK J Paediatr (New Series)
Vol 16. No. 4, 2011

HK J Paediatr (New Series) 2011;16;253-257

Original Article

Neonatal Sepsis Caused by Gram-negative Bacteria in a Neonatal Intensive Care Unit: A Six Years Analysis

M Mutlu, Y Aslan, B Saygin, G Yilmaz, G Bayramoğlu, I Köksal


Objective: To analyse the Gram-negative bacteriological profile of nosocomial sepsis and antibiotic susceptibility patterns. Methods: Neonates clinically diagnosed with sepsis and whose blood cultures tested positive for Gram-negative microorganisms from 2002 to 2008, retrospectively. Results: 143 cases of neonatal sepsis caused by Gram-negative microorganisms were identified. Eighty-one percent (n=116) of these had nosocomial sepsis. In nosocomial sepsis, the most common isolated Gram-negative micro-organism was Serratia marcescens (16.4%). Levofloxacin (97.4%), meropenem (97.1%), imipenem (95.6%), ciprofloxacin (95.4%) and amikacin (94.8) were the most sensitive antibiotics to Gram-negative micro-organisms. Sepsis-related mortality rate was 16% (n=23) in nosocomial sepsis caused by Gram-negative microorganisms. Conclusions: Carbapenem seems to be the best option for nosocomial sepsis caused by Gram-negative micro-organisms in our neonatal intensive care unit. Every unit must evaluate causative agents and antimicrobial susceptibilities in order to select the appropriate empirical therapy for nosocomial sepsis.

Keyword : Antibiotic susceptibility; Gram-negative bacteria; Newborn; Nosocomial sepsis

Abstract in Chinese


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