Epidemiology and Prognosis of Childhood Epilepsy in Hong Kong: Literature Review
The present study summarises relevant articles on the epidemiology of childhood epilepsy in the local scene published over the past twenty years. We performed a search of the Medline and a manual search of Hong Kong Medical Journal, Hong Kong Practitioner, Hong Kong Journal of Paediatrics, Chinese Medical Journal using the key words 'epilepsy', 'children' and 'Hong Kong'. Overall, the prevalence of childhood epilepsy in Hong Kong can be estimated and the natural history of seizures in our patients can be better determined. Disorders using International League Against Epilepsy classifications, such as Lennox-Gastaut syndrome, benign childhood epilepsy with centrotemporal spikes, childhood absence epilepsy and juvenile myoclonic epilepsy are increasingly being recognised in Hong Kong. Aetiologies of epilepsies could be delineated in a great proportion of patients. Early predictors of medical intractability were identified. CNS infection and perinatal hypoxic-ischaemic encephalopathy were common causes of remote symptomatic epilepsy and the resulting seizures were often medically intractable.
本研究總結了該地過去二十年內發表的有關兒童期癲癇流行病學的文章。我們以 'epilepsy' 、 'children' 與 'Hong Kong' 為關鍵詞檢索了 Medline、香港醫學雜誌、香港全科醫學院月刊、香港兒科醫學雜誌和中華醫學雜誌（英文版）。總體上，能夠對該地兒童期癲癇的發病率以及對患者癲癇發作的自然病史進行較好的評估。根據國際抗癲癇聯盟的分類命名，諸如 Lennox-Gastaut 綜合徵、伴中央顳區棘波的兒童期良性癲癇、兒童失神癲癇及青少年肌陣攣性癲癇等病在香港正逐漸被認識。大部分患者身上能找到癲癇的病因學信息。本研究鑒定了難治性癲癇的早期指標。中樞神經系統感染和圍產期缺氧缺血性腦病是發生遠期症狀性癲癇的常見原因，引致癲癇發作經常難於治療。
Keyword : Children; Epilepsy; Hong Kong
Epilepsy is one of the most common neurologic disorders in childhood. It is defined as two or more unprovoked seizures more than 24 hours apart in a child over 1 month of age.1 In the past, epilepsy was considered to be a progressive, non-remitting disease. Gowers, who studied epileptic patients seen in tertiary referral centers, once mentioned:"The tendency of the disease is towards self-perpetuation; each attack facilitates the occurrence of another by increasing the instability of the nerve elements.... The cases in which the best results are obtained... are precisely, those who are never heard again."2 In his brief comment, Gowers identified the important role played by epidemiology in the study of epilepsy. Guidelines had been developed by the International League Against Epilepsy for the classification of seizures and epilepsy syndromes, as well as for epidemiologic research in epilepsy.1,3,4 Over the past two decades, studies have expanded our understanding of the epidemiology and prognosis of seizures, which is at times contrary to long-held beliefs. This article reviews data on the epidemiology and prognosis of childhood epilepsy in the local scene.
We performed a search of the electronic database Medline using the key words "epilepsy", "children" and "Hong Kong". We also conducted a manual search of Hong Kong Medical Journal, Hong Kong Practitioners, Hong Kong Journal of Paediatrics, Chinese Medical Journal between 1986 and 2006. All original articles were reviewed.
Inclusion and Exclusion Criteria
Children with only febrile seizures, acute symptomatic seizures, isolated seizures and neonatal seizures were excluded. Adult-based studies of epilepsy were also excluded if the major proportion of patients studied were adults.
The number of relevant articles on epidemiology and prognosis of childhood epilepsy in Hong Kong was twelve.5-16 Specific aspects of these studies were reviewed and presented as follows:
The prevalence rate of active epilepsy for children under 15 years of age was reported by Kwong et al to be 1.52/1000 on July 1, 1997. Prevalence rates increased with age and were higher in boys. Age of seizure onset was observed to be highest in the first year of life and declines thereafter.5 According to another study conducted in a teaching hospital, the period prevalence rate of epilepsy in 1997 was estimated to be 4.5 per 1000 children less than 19 years of age.6 A figure of 1.54 per 1000 had been reported in a territory-wide survey among adult epileptic patients.17 Direct comparison of data derived by the above studies was difficult because of different sources of patient referral and methodologies.
Epilepsy is a heterogeneous group of disorder from both clinical and aetiologic points of view. Idiopathic epilepsy accounted for 40% of childhood epilepsies.5 Discrepancy was observed in the proportion of cryptogenic and symptomatic epilepsies. The frequency of cryptogenic epilepsy was reported to be 0.9% in a cohort of epileptic children according to a study conducted in a teaching hospital, a much lower figure when compared to 16.8% in another survey in a regional hospital.5,6 Sources of patient referral could partly explain such a difference. According to important overseas studies published during recent years. The percentage of cryptogenic epilepsies ranges between 20.7-44.4%. Aetiologies in symptomatic epilepsy could be traced in 30-61% of cases, but these figures were not fully comparable.18-20 It is possible that the yield of aetiologies could have been much higher if neuroimaging, especially MRI brain, had been performed in all children. The causes were prenatal in 27%, perinatal 28% and postnatal 45%.5 The three most common causes were CNS infections, CNS malformations and perinatal hypoxic-ischaemic encephalopathy.5,6
Seizure Types and Epileptic Syndromes
In the past, it was generally believed that childhood epilepsies were mostly generalised, but more recent studies published overseas have shown that this is not the case. Newer data indicate that the majority of seizures and epileptic syndromes are partial.18,20,21 Furthermore, more benign epileptic syndromes, such as benign childhood epilepsy with centrotemporal spikes and childhood absence epilepsy, account for a substantial proportion of childhood epilepsies in community-based samples.20-22 Disorders using International League Against Epilepsy classifications, such as Lennox-Gastaut syndrome, benign childhood epilepsy with centrotemporal spikes, childhood absence epilepsy and juvenile myoclonic epilepsy are increasingly being recognised in Hong Kong.7 Generalised tonic-clonic seizures and partial seizures secondarily generalised were the most frequent seizure subtypes. The proportion of partial epilepsies and generalised epilepsies was almost equal as reported in one study.5 Benign childhood epilepsy with centrotemporal spikes was observed in 7% and childhood absence epilepsy in 6% of epileptic children aged less than 15 years in one study.5
Epilepsy and Neurodevelopmental Impairments
The association between epilepsy and cerebral palsy and/or mental retardation is well recognised. According to overseas publications, about 15-30% of childhood-onset epilepsy is associated with these conditions.19,23 Conversely, epilepsy is a common co-morbid condition in children with developmental disabilities. Additional neuroimpairments were observed in 36% of our epileptic children in one study, in which mental impairments were more common than motor disability.6 Epilepsy occurred in 37% of children with cerebral palsy.8 The frequency was highest in spastic tetraplegia. Factors associated with development of epilepsy in children with cerebral palsy were mental subnormality.8 When compared to neurologically normal children with epilepsy, children with cerebral palsy had a higher incidence of epilepsy with onset in the first year of life, status epilepticus, polytherapy, persistent seizures and multiple seizure types.8 Wong found that 7.6% of children with autistic spectrum disorders have recurrent seizures.9 Kwong & Wong had reported that only 2 (1.6%) of the 124 children with Down's syndrome had epilepsy, a percentage much lower than other case series reported.10 Children with infantile spasms were associated with a poor neurodevelopmental outcome, multiple disabilities were observed in 15%, cerebral palsy in 21% and mental retardation in 90% of patients.11 Epilepsy was the co-morbidity in 48% of patients with tuberous sclerosis.12 Factors associated with development of infantile spasms in tuberous sclerosis were tubers in parietal and occipital regions.12
A retrospective review of 37 children admitted to a teaching hospital with the diagnosis of status epilepticus from 1986 to 1993 showed that the mortality was 11%. Mortality was attributed to the underlying causes. Neurological sequalae was observed in 27% of survivors and recurrent status epilepticus developed in 12% of patients. Acute CNS insults accounted for 60% of status epilepticus. This is followed by idiopathic aetiology in 11%, previous CNS insults 13% and febrile illness 5% of cases.13 The same author in another study of status epilepticus observed that symptomatic aetiology and refractory status epileptics were associated with adverse outcomes. Young age at status epilepticus (<12 months) and duration of seizures more than 60 minutes tended to be more frequent among those with poorer outcome.14 Rectal diazepam given before hospital arrival was only observed in one sixth of patients.14 Prompt use of rectal diazepam by caretakers or paramedical should be encouraged may help to prevent refractory status epilepticus.
Wong reported 54% of the cohort with epilepsy had complete seizure remission.6 Epilepsy in children with neuroimpairments had less favorable outcome. Only 37% of children with cerebral palsy had good seizure control, i.e. seizure-free for at least 2 years.8 Factors associated with seizure-free status among children with cerebral palsy were normal intelligence, single seizure types, seizure responsive to monotherapy and spastic diplegia.8 In a cohort of children with benign childhood epilepsy with centrotemporal spikes, none of the patients experienced seizures beyond 15 years of age.7
Lack of remission was not synonymous as intractability. Patients not in remission include those with infrequent seizures owing to non-compliance with medications, or infrequent seizures not being treated. Medical intractability was defined as uncontrolled seizures occurring with an average frequency of at least 1 seizure per month over an observational period of 2 years or more despite treatment with at least 3 different antiepileptic drugs, singly or in combination.23,24 Fourteen percent of a cohort of local epileptic children experienced medically intractable epilepsy.15 Early predictors of intractability were identified in that study were as follows: high initial seizure frequency, remote symptomatic aetiology, infantile spasms, mixed seizure types, history of status epilepticus, history of neonatal seizures and early breath-through seizures after treatment initiation. Independent predictors of intractability were abnormal neurodevelopmental staus, remote symptomatic aetiology and lack of early response to treatment.15 The risk of medical intractability was highest among the symptomatic localisation group. Among children with intractable epilepsy, CNS infections accounted for 24% and 28% of cases. Neuroimaging was essential in the evaluation of intractable epilepsy. Abnormalities were detected in two-third of patients.15
According to a local questionnaire survey among parents with epileptic children in a regional hosptial, the main family concerns were seizures, school performance and side effects of medications.16 Half of the patients complained that their children were more restless and short-tempered. Half of them worried that epilepsy was incurable. One-fifth thought that swimming should be prohibited even if seizures were controlled and 15% were afraid that their children would die during the seizure attacks. The majority of parents requested more information about epilepsy and closer communication between teachers and physicians.16
Research pursuits within the epidemiology of epilepsy have come a long way from the days of simply counting how many people had seizures. By combining improvement in classification systems, diagnostic technology and methods for case ascertainment, our understanding of epidemiology was strengthened. Local epidemiological data on childhood epilepsy are important in order to assess the magnitude of this problem and to target resources to patients who are most in need. Besides, identification of the aetiology of epilepsy can hopefully result in possible prevention of this common disorder. The findings are also important for paediatricians in determining an effective course of treatment, as well as communicating the illness, recurrence rates, and long-term prognosis to parents. This review summaried the recent data on epidemiology and prognosis of childhood epilepsies in the local population.
Review of the literature on epidemiological studies shows that the prevalence of epilepsy ranges from 4-7 per 1000 population.23,25,26 Incidence rates are typically between 30 and 50 per 100,000 population per year.23,25,26 A bimodal incidence of unprovoked seizures was observed at the extremes of age.25,26 According to studies conducted in other Chinese communities, the prevalence is 4 to 7 per 1000 population.27-30 Our prevalence rate is somewhat lower than that reported in other epidemiological studies. Factors such as geographic origins, socio-economic situations, study designs and methodology are of importance in accounting for the differences. Some studies include neonates and patients with single unprovoked seizures. The majority of patients could be classified according to the International League Against Epilepsy classifications of epileptic seizures and epileptic syndromes. Neuroimaging had been widely used in the evaluation of epilepsy. CT scan was performed in 69% and MRI 54% in a cohort of epileptic children.6 This figure of neuroimaging was highly comparable to some of the studies carried out in the western countries. Neuroimaging was performed in 75% of epileptic children and out of which 85% had MRI according to a recent study reported by Larsson & Eeg-Olofsson.31 Whereas in another study by Endziene et al, CT scan brain was performed in only 16% of patients.32 The three most common causes of childhood epilepsy identified in the local population were CNS infections, CNS malformations and perinatal hypoxic-ischaemic encephalopathy. Studies in Taiwan and South Korea similarly identified perinatal hypoxic-ischaemic encephalopathy, congenital brain anomalies and tuberous sclerosis being the commonest aetiologies for infantile spasms.33,34 There is some evidence suggesting that the incidence of epilepsy may have declined in the last decades. If one analyses the causes of epilepsy, probably more effective vaccines against pathogens causing meningitis and improved perinatal care could have decreased our disease burden.
The proportion of children who experienced medically intractable epilepsy was comparable to a multi-institutional study on intractable epilepsy in Japan, in which the frequency was 13%.35 Ten percent of the cohort reported by Berg et al met the criteria of intractability early in the course of their disorders.36 The discrepancy in frequency can be explained by the true differences in various socioeconomic and geographical situations. The variability also reflects the lack of a standard and well-accepted definition of intractable epilepsy. Early identification of patients who are at high risk of developing intractable epilepsy is essential in parental counselling and selecting patients for more intensive investigations and treatment, such as epilepsy surgery. Almost all the associations of intractability included aetiology, age of onset under 1 year and with abnormal neurology was explained by the syndromic grouping.24,37 Regarding the aetiology, CNS infection and perinatal hypoxic-ischaemic encephalopathy was identified to be the most important causes of intractable epilepsy according to our local data. Similarly, in a study of infantile spasms conducted in Taiwan, the prognosis of West syndrome was heavily dependent on whether the aetiology was cryptogenic or symptomatic.38 In Casetta's series of intractable epilepsy, perinatal brain injuries predominated, while the most characteristic finding of underlying causes in intractable localisation-related epilepsy was CNS infection in Ohtsuka's study.37,39 In the acute stage of CNS infection and perinatal hypoxic-ischaemic encephalopathy, patients often experienced repeated status epilepticus or frequent seizures requiring intensive care. Seizures in the acute stage often originate from several different regions of the brain in the individual patient, and multifocal seizures continue after the acute stage. These patients are often resistant to medication. Whether improvement in prevention of acute CNS infection and perinatal care can result in decreasing the proportion of intractable epilepsy awaits further studies.
Half of the families of our children with epilepsy worried that epilepsy was an incurable disease and one-sixth were afraid of death due to seizures. This negative attitude was also observed in Korea and some parts of China.40-42 On the other hand, the attitude towards epilepsy was more favorable in Taiwan.43 Parental anxiety outweighed the physical factors in determining quality of life in childhood epilepsy. Public health education is urgently needed in order to improve the quality of life among children with epilepsy.
In summary, our studies have provided useful information on the prevalence of childhood epilepsy in the local population and the natural history of seizures. Knowledge gaps clearly exist in many aspects of childhood epilepsy. For instance, although current data suggests the prognosis of childhood-onset epilepsy is relatively favorable in terms of seizure remission, we need data on its long-term impact on education and social outcomes. There are various reasons that made these outcomes unclear. Social and academic limitations may be attritable not only to natural course of epilepsy, but also to medications, underlying disease and/or, inaccurate and inappropriate social stigmatisation about epilepsy. It is clear that the optimal treatment of childhood epilepsy needs to encompass the child's entire well-being and not limit solely to achieving seizure control.
1. Guidelines for epidemiologic studies on epilepsy. Commission on Epidemiology and Prognosis, International League Against Epilepsy. Epilepsia 1993;34:592-6.
2. Gowers WR. Epilepsy and other chronic convulsive disorders: their causes, symptoms and treatment. London: J&A Churchill, 1881.
3. Proposal for revised clinical and electroencephalographic classification of epileptic seizures. From the Commission on Classification and Terminology of the International League Against Epilepsy. Epilepsia 1981;22:489-501.
4. Proposal for revised classification of epilepsies and epileptic syndromes. Commission on Classification and Terminology of the International League Against Epilepsy. Epilepsia 1989;30:389-99.
5. Kwong KL, Chak WK, Wong SN, So KT. Epidemiology of childhood epilepsy in a cohort of 309 Chinese children. Pediatr Neurol 2001;24:276-82.
6. Wong V. Study of seizure and epilepsy in Chinese children in Hong Kong: period prevalence and patterns. J Child Neurol 2004;19:19-25.
7. Ma CK, Chan KY. Benign childhood epilepsy with centrotemporal spikes: a study of 50 Chinese children. Brain Dev 2003;25:390-5.
8. Kwong KL, Wong SN, So KT. Epilepsy in children with cerebral palsy. Pediatr Neurol 1998;19:31-6.
9. Wong V. Epilepsy in children with autistic spectrum disorder. J Child Neurol 1993;8:316-22.
10. Kwong KL, Wong V. Neurodevelopmental profile of Down syndrome in Chinese children. J Paediatr Child Health 1996;32:153-7.
11. Wong V. West syndrome--The University of Hong Kong experience (1970-2000). Brain Dev 2001;23:609-15.
12. Wong V, Khong PL. Tuberous sclerosis complex: correlation of magnetic resonance imaging (MRI) findings with comorbidities. J Child Neurol 2006;21:99-105.
13. Kwong KL, Lee SL, Yung A, Wong VC. Status epilepticus in 37 Chinese children: aetiology and outcome. J Paediatr Child Health 1995;31:395-8.
14. Kwong KL, Chang K, Lam SY. Features predicting adverse outcomes of status epilepticus in childhood. Hong Kong Med J 2004;10:156-9.
15. Kwong KL, Sung WY, Wong SN, So KT. Early predictors of medical intractability in childhood epilepsy. Pediatr Neurol 2003;29:46-52.
16. Kwong KL, Wong SN, So KT. Parental perception, worries and needs in children with epilepsy. Acta Paediatr 2000;89:593-6.
17. Ng KK, Ng PW, Tsang KL; Hong Kong Epilepsy Study Group. Clinical characteristics of adult epilepsy patients in the 1997 Hong Kong epilepsy registry. Chin Med J (Engl) 2001;114:84-7.
18. Berg AT, Shinnar S, Levy SR, Testa FM. Newly diagnosed epilepsy in children: presentation at diagnosis. Epilepsia 1999;40:445-52.
19. Jallon P, Loiseau P, Loiseau J. Newly diagnosed unprovoked epileptic seizures: presentation at diagnosis in CAROLE study. Coordination Active du Reseau Observatoire Longitudinal de l' Epilepsie. Epilepsia 2001;42:464-75.
20. Callenbach PM, Geerts AT, Arts WF, et al. Familial occurrence of epilepsy in children with newly diagnosed multiple seizures: Dutch Study of Epilepsy in Childhood. Epilepsia 1998;39:331-6.
21. Shinnar S, O'Dell C, Berg AT. Distribution of epilepsy syndromes in a cohort of children prospectively monitored from the time of their first unprovoked seizure. Epilepsia 1999;40:1378-83.
22. Sillanpaa M, Jalava M, Shinnar S. Epilepsy syndromes in patients with childhood-onset seizures in Finland. Pediatr Neurol 1999;21:533-7.
23. Shinnar S, Pellock JM. Update on the epidemiology and prognosis of pediatric epilepsy. J Child Neurol 2002;17 Suppl 1:S4-17.
24. Berg AT, Levy SR, Novotny EJ, Shinnar S. Predictors of intractable epilepsy in childhood: a case-control study. Epilepsia 1996;37:24-30.
25. Camfield CS, Camfield PR, Gordon K, Wirrell E, Dooley JM. Incidence of epilepsy in childhood and adolescence: a population-based study in Nova Scotia from 1977 to 1985. Epilepsia 1996;37:19-23.
26. Berg AT. Epidemiologic aspects of epilepsy. In Wyllie E, Gupta A, Lachhwani DK (eds): The treatment of epilepsy, 4th Edition. Lippincott Williams & Wilkins, 2006.
27. Wang WZ, Wu JZ, Wang DS, et al. The prevalence and treatment gap in epilepsy in China: an ILAE/IBE/WHO study. Neurology 2003;60:1544-5.
28. Li SC, Schoenberg BS, Wang CC, Cheng XM, Zhou SS, Bolis CL. Epidemiology of epilepsy in urban areas of the People's Republic of China. Epilepsia 1985;26:391-4.
29. Chi CS. Improvement of modern treatment and outcome in childhood epilepsy in Asia. Acta Paediatr Jpn 1989;31:278-85.
30. Tan CT, Lim SH. Epilepsy in South East Asia. Neurol J Southeast Asia 1997;2:11-5.
31. Larsson K, Eeg-Olofsson O. A population based study of epilepsy in children from a Swedish county. Eur J Paediatr Neurol 2006;10:107-13.
32. Endziniene M, Pauza V, Miseviciene I. Prevalence of childhood epilepsy in Kaunas, Lithuania. Brain Dev 1997;19:379-87.
33. Hwang YS; Korean Child Neurology Society. National survey on West syndrome in Korea. Brain Dev 2001;23:565-9.
34. Liou HH, Oon PC, Lin HC, Wang PJ, Chen TH. Risk factors associated with infantile spasms: a hospital-based case-control study in Taiwan. Epilepsy Res 2001;47(1-2):91-8.
35. Ohtahara S, Ohtsuka Y, Tada K. A multi-institutional study on the refractory epilepsy in childhood. Annual report of research: Cause and treatment of refractory epilepsies. Tokyo Ministry of Health and welfare of Japan, 1985;13-21.
36. Berg AT, Shinnar S, Levy SR, Testa FM, Smith-Rapaport S, Beckerman B. Early development of intractable epilepsy in children: a prospective study. Neurology 2001;56:1445-52.
37. Casetta I, Granieri E, Monetti VC, et al. Early predictors of intractability in childhood epilepsy: a community-based case-control study in Copparo, Italy. Acta Neurol Scand 1999;99:329-33.
38. Lin HC, Young C, Wang PJ, Lee WT, Shen YZ. ACTH therapy for Taiwanese children with West syndrome -- efficacy and impact on long-term prognosis. Brain Dev 2006;28:196-201.
39. Ohtsuka Y, Yoshinaga H, Kobayashi K, et al. Predictors and underlying causes of medically intractable localization-related epilepsy in childhood. Pediatr Neurol 2001;24:209-13.
40. Lai CW, Huang XS, Lai YH, Zhang ZQ, Liu GJ, Yang MZ. Survey of public awareness, understanding, and attitudes toward epilepsy in Henan province, China. Epilepsia 1990;31:182-7.
41. Yong L, Chengye J, Jiong Q. Factors affecting the quality of life in childhood epilepsy in China. Acta Neurol Scand 2006;113:167-73.
42. Choi-Kwon S, Park KA, Lee HJ, et al. Familiarity with, knowledge of, and attitudes toward epilepsy in residents of Seoul, South Korea. Acta Neurol Scand 2004;110:39-45.
43. Chung MY, Chang YC, Lai YH, Lai CW. Survey of public awareness, understanding, and attitudes toward epilepsy in Taiwan. Epilepsia 1995;36:488-93.