Table of Contents

HK J Paediatr (New Series)
Vol 12. No. 2, 2007

HK J Paediatr (New Series) 2007;12:96-100

Special Article

Pulmonary Inflammation and the Role of Pre- and Postnatal Factors in the Pathogenesis of BPD

CP Speer


Abstract

Bronchopulmonary dysplasia (BPD) is an evolving process of lung injury and aberrant wound healing. An imbalance between proinflammatory and anti-inflammatory mediators, favouring proinflammatory mechanisms, and an impaired generation of growth factors which are crucial for a normal pulmonary development have been identified as central factors in the pathogenesis of BPD. Pre- and postnatal events such as chorioamnionitis and various interventions of neonatal intensive care induce an injurious inflammatory response in the immature airways and the pulmonary interstitium of preterm infants which may subsequently affect normal alveolarisation and vascular development of the immature lungs.

Keyword : Bronchopulmonary dysplasia; Cytokines; Growth factors; Oxidative damage; Preterm infants


Abstract in Chinese

 
 

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