Table of Contents

HK J Paediatr (New Series)
Vol 11. No. 3, 2006

HK J Paediatr (New Series) 2006;11:179-185

Immunology & Infectious Diseases Forum

IL1B Promoter Haplotypes Are Associated with Spirometric Indices and Plasma Total IgE in Chinese Children

TF Leung, IHS Chan, GWK Wong, NLS Tang, SL Ma, CWK Lam, TF Fok, PC Ng


Abstract

Interleukin (IL)-1 gene family encodes for pleiotropic pro-inflammatory and anti-inflammatory cytokines. Genome screens mapped asthma phenotypes to chromosome 2q12-21 where IL-1 gene cluster is located. This study investigated the relation between asthma traits and polymorphisms at positions -31 and -511 of IL-1β gene (IL1B) in Chinese children. Plasma total IgE and allergen-specific IgE concentrations were measured by immunoassays. IL1B promoter genotypes were characterised by restriction fragment length polymorphism. One hundred and fifty-eight patients and 56 controls were recruited. Significant inter-ethnic variations in allele frequencies of IL1B were found between Chinese and other populations. Neither IL1B polymorphisms was associated with asthma. However, patients homozygous for IL1B -31C had lower FEV1 (p=0.03) and FVC (p=0.008). More subjects with IL1B -31C/-511T haplotype had increased plasma total IgE (OR 1.61, 95%CI 1.02-2.54; p=0.04) and decreased FEV1 (OR 1.78, 95%CI 1.06-3.02; p=0.03) and FVC (OR 1.87, 95%CI 1.09-3.22; p=0.02). In conclusion, IL1B promoter polymorphisms are associated with poorer lung function and increased plasma total IgE concentration in Chinese children.

Keyword : Asthma; Atopy; Chinese; Interleukin-1β gene; Spirometry


Abstract in Chinese

 
 

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