Table of Contents

HK J Paediatr (New Series)
Vol 11. No. 1, 2006

HK J Paediatr (New Series) 2006;11:45-49

Original Article

Ototoxicity in Chinese Osteosarcoma Children Treated with Cisplatin

CM Chow, NC Sin, KW Chik, V Lee, MK Shing, CK Li


Objective: To evaluate the ototoxicity of cisplatin in Chinese children who were suffered from osteosarcoma. Patients & Methods: Restrospective case series of Chinese children who were treated in a tertiary referral centre of Hong Kong. Data was based on hospital records of children who were suffering from osteosarcoma between 1994 and 2001. They all have cisplatin treatment with pre- and post-chempotherapy pure tone audiometry results. Results: Sixteen patients fulfied the inclusion criterias were studied. Nineteen percent had grade I hearing impairment even at baseline evaluation. Sixty-nine percent showed worsening of the hearing after cisplatin treatment. The hearing threshold was increased at 2000Hz after cisplatin, which was more clearly shown at 4000Hz and 8000Hz. The results were statistically significant with the p-value 0.011, 0.003 and 0.002 respectively. Conclusion: Cisplatin would damage the hearing particularly at high frequency range (2000Hz, 4000Hz and 8000Hz). The hearing at low frequency range was relatively spare.

Keyword : Cisplatin; Osteosarcoma; Ototoxicity

Abstract in Chinese


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