Table of Contents

HK J Paediatr (New Series)
Vol 21. No. 1, 2016

HK J Paediatr (New Series) 2016;21:39-42

Case Report

Primary Intra-Renal Neuroblastoma - A Diagnostic Dilemma: A Case Report

PMY Tang, MWY Leung, NSY Chao, KKW Liu


Abstract

Background: Primary intra-renal neuroblastoma is a rare tumour of the kidney in children. We report a case that mimicked Wilms' tumour. Method: A 15-month-old boy was referred to our hospital with incidental finding of a 10 cm left abdominal mass. Computerised tomography scan showed a left kidney tumour resembling Wilms' tumour. Metaiodobenzylguanidine scan showed no abnormal update of the sympathetic-nervous-system. Bone marrow aspiration was negative for malignant cells. In view of the clinical diagnosis of Wilms' tumour of the left kidney, exploratory laparotomy was performed and revealed a normal left adrenal gland with large tumour arising from the left kidney. Radical left nephrectomy with para-aortic lymph node dissection was performed. Results: The pathological report showed intra-renal neuroblastoma of the left kidney. Molecular genetic studies confirmed N-myc amplification. The result for the 24-hour urine, collected pre-operatively, showed elevated catecholamines level. The diagnosis of a primary intra-renal neuroblastoma was confirmed and adjuvant therapy was started. Conclusions: Primary intra-renal neuroblastoma may pose as a diagnostic challenge pre-operatively as it may clinically and radiographically resemble Wilms' tumour. With our literature search, this is the first case report on a primary intra-renal neuroblastoma in a Chinese child. Clinical, radiological and pathological correlation is essential in the management of primary intra-renal neuroblastoma.

Keyword : Diagnosis; Intra-renal neuroblastoma; Wilms' tumour


Abstract in Chinese

 
 

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